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Levosimendan for amyotrophic lateral sclerosis

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2021 Portugal English Publisher:Elsevier BVJournal:The Lancet Neurology, volume 20, pages 775-777 (issn: 1474-4422,

Authors: Carvalho, Mamede; Swash, Michael;

doi: 10.1016/s1474-4422(21)00255-6

pmid: 34536395

handle: 10451/49848

Levosimendan for amyotrophic lateral sclerosis

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Abstract

Levosimendan is a drug developed and approved in the EU to treat severe heart failure by intravenous administration. Its principal pharmacological effect is to increase cardiac contractility by calcium sensitisation of troponin C. Because of the positive action of the drug on the neuromechanical efficiency and contractile function of the diaphragm in healthy controls, levosimendan was considered potentially useful for treating amyotrophic lateral sclerosis, a disease characterised by progressive upper and lower motor neuron deficits. This hypothesis was tested in the phase LEVALS 2 trial, in which the drug was given orally.

Country

Portugal

Related Organizations

Queen Mary University of London
United Kingdom
Hospital de Santa Maria
Portugal
University of Lisbon
Portugal
Universidade de Lisboa
Portugal
St. Stephen’s Hospital
India

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Keywords

Amyotrophic Lateral Sclerosis, Humans, Simendan

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