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Electrochemistry of anti-HIV agents

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2000Publisher:Elsevier BVJournal:Electrochemistry Communications, volume 2, pages 244-247 (issn: 1388-2481,

Authors: Yufei Cheng; S.C. Lemoult; David J. Schiffrin; Kyösti Kontturi;

doi: 10.1016/s1388-2481(00)00012-6

Electrochemistry of anti-HIV agents

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Abstract

Square wave voltammetry has been used to study the electrochemical behaviour of anti-HIV drugs in aqueous solutions. The oxidation reaction of Carbovir (1) at a Pt microelectrode occurs at 1.12 V versus SCE and the peak current is proportional to the concentration. An electroanalytical technique for the determination of trace concentrations of Carbovir (1) is proposed and experimental conditions have been optimised. The effect of Cu(II) on the electrochemistry of nucleosides and nucleotides has also been studied. An equilibrium between the nucleotide-copper complex formed and the free nucleotide is observed.

Related Organizations

University of Liverpool
United Kingdom
Helsinki University of Technology
Finland

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