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The CC chemokine CCL20 and its receptor CCR6

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2003Publisher:Elsevier BVJournal:Cytokine & Growth Factor Reviews, volume 14, pages 409-426 (issn: 1359-6101,

Authors: Sofie Struyf; Jozef Van Damme; Evemie Schutyser;

doi: 10.1016/s1359-6101(03)00049-2

pmid: 12948524

The CC chemokine CCL20 and its receptor CCR6

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Abstract

CCL20, alternatively named liver and activation-regulated chemokine (LARC), macrophage inflammatory protein-3alpha (MIP-3alpha) or Exodus-1, is the only chemokine known to interact with CC chemokine receptor 6 (CCR6), a property shared with the antimicrobial beta-defensins. The ligand-receptor pair CCL20-CCR6 is responsible for the chemoattraction of immature dendritic cells (DC), effector/memory T-cells and B-cells and plays a role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and rheumatoid arthritis. In this review, the discovery, the gene and protein structure, the in vitro biological activities, the cell and inducer specific expression and the tissue distribution of CCL20 and CCR6 are discussed.

Related Organizations

Rega Institute for Medical Research
Belgium

Keywords

Receptors, CCR6, Chemokine CCL20, Molecular Sequence Data, Macrophage Inflammatory Proteins, Arthritis, Rheumatoid, Chemokines, CC, Leukocytes, Animals, Homeostasis, Humans, Receptors, Chemokine, Amino Acid Sequence, Sequence Alignment

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Faculty Opinions recommendation of The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins.
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