descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2001 English Publisher:Elsevier BVJournal:Microbes and Infection, volume 3, pages 851-857 (issn: 1286-4579,

Authors: GINALDI, Lia; Loreto MF; Corsi MP; Modesti M; DE MARTINIS, MASSIMO MARIA MARCELLO;

doi: 10.1016/s1286-4579(01)01443-5

pmid: 11580980

handle: 11697/10937

Immunosenescence and infectious diseases

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Abstract

Infectious diseases are major causes, with malignancies, of morbidity and mortality in the elderly. Increased susceptibility to infections may result from underlying dysfunction of an aged immune system; moreover, inappropriate immunologic functions associated with aging can determine an insufficient response to vaccines. Impairments of cellular, humoral and innate immunity in the elderly, contributing to increased incidence of infectious diseases, are discussed in this review.

Related Organizations

University of L'Aquila
Italy

Keywords

immunosenescence; immunity; aging, Aging, Vaccines, Immune System, Animals, Humans, Communicable Diseases

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