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Recruitment of proteins to modulate protein-protein interactions

Name: Recruitment of proteins to modulate protein-protein interactions
Creator: Jun O. Liu
Keywords: Pharmacology, 0301 basic medicine, 0303 health sciences, Clinical Biochemistry, Membrane Proteins, Proteins, Biochemistry, 3. Good health, 03 medical and health sciences, Drug Discovery

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1999Publisher:Elsevier BVJournal:Chemistry & Biology, volume 6, pages R213-R215 (issn: 1074-5521,

Authors: Jun O. Liu;

doi: 10.1016/s1074-5521(99)80080-5

pmid: 10421765

Recruitment of proteins to modulate protein-protein interactions

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Abstract

The use of a 'borrowed' protein surface to either enhance or inhibit the interaction of a small ligand with its protein target has been reported recently. This approach represents a general method for modulating protein-protein interactions and may find many applications in both biology and medicine.

Related Organizations

Massachusetts Institute of Technology
United States
SPENCER
Center for Cancer Research
United States
Spencer
National Cancer Institute
United States

Keywords

Pharmacology, Clinical Biochemistry, Membrane Proteins, Proteins, Biochemistry, Drug Discovery, Molecular Medicine, Animals, Humans, Molecular Biology, Signal Transduction

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