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Antagonists of protein–protein interactions

Name: Antagonists of protein–protein interactions
Creator: Andrea G. Cochran
Keywords: Pharmacology, Models, Molecular, 0301 basic medicine, 0303 health sciences, Binding Sites, Clinical Biochemistry, Molecular Sequence Data, Biochemistry, Binding, Competitive, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2000Publisher:Elsevier BVJournal:Chemistry & Biology, volume 7, pages R85-R94 (issn: 1074-5521,

Authors: Andrea G. Cochran;

doi: 10.1016/s1074-5521(00)00106-x

pmid: 10779412

Antagonists of protein–protein interactions

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Abstract

Protein-protein interactions are often attractive, but not straightforward, targets for disease therapy. Two strategies for identifying inhibitors of these interactions, peptide phage display and high-throughput screening, have recently shown new promise.

Related Organizations

GENENTECH INC
United States

Keywords

Pharmacology, Models, Molecular, Binding Sites, Clinical Biochemistry, Molecular Sequence Data, Biochemistry, Binding, Competitive, Peptide Library, Drug Design, Drug Discovery, Molecular Medicine, Amino Acid Sequence, Molecular Biology, Dimerization, Protein Binding

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	242
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%