Splicing: HACking into the unfolded-protein response
Copyright policy )Splicing: HACking into the unfolded-protein response
Unfolded proteins in the endoplasmic reticulum of Saccharomyces cerevisiae trigger a specialized RNA splicing event that allows the subsequent translation of the Hac1p transcription factor. This splicing can be reconstituted with Ire1p, a transmembrane kinase that has a site-specific RNase activity, and tRNA ligase.
- Harvard University United States
Protein Folding, Saccharomyces cerevisiae Proteins, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), RNA Splicing, Saccharomyces cerevisiae, Fungal Proteins, Repressor Proteins, Basic-Leucine Zipper Transcription Factors, Protein Biosynthesis, RNA, Messenger, Transcription Factors
Protein Folding, Saccharomyces cerevisiae Proteins, Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all), RNA Splicing, Saccharomyces cerevisiae, Fungal Proteins, Repressor Proteins, Basic-Leucine Zipper Transcription Factors, Protein Biosynthesis, RNA, Messenger, Transcription Factors
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