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Helicase structure and mechanism

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2002Publisher:Elsevier BVJournal:Current Opinion in Structural Biology, volume 12, pages 123-133 (issn: 0959-440X,

Authors: Jonathan M. Caruthers; David B. McKay;

doi: 10.1016/s0959-440x(02)00298-1

pmid: 11839499

Helicase structure and mechanism

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Abstract

Structural information on helicase proteins has expanded recently beyond the DNA helicases Rep and PcrA, and the hepatitis C virus RNA helicase to include UvrB, members of the DEA(D/H)-box RNA helicase family, examples of DnaB-related helicases and RuvB. The expanding database of structures has clarified the structural 'theme and variations' that relate the different helicase families. Furthermore, information is emerging on the functions of the conserved helicase motifs and their participation in the mechanisms by which these proteins catalyze the remodeling of DNA and RNA in ATP-dependent activities.

Related Organizations

Stanford University
United States

Keywords

Protein Conformation, Amino Acid Motifs, DNA Helicases, Sequence Homology, Structure-Activity Relationship, Bacterial Proteins, Multigene Family, DnaB Helicases, Conserved Sequence, RNA Helicases

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