Multisubunit RNA polymerases
Copyright policy )Multisubunit RNA polymerases
Transcription of the genetic information in all cells is carried out by multisubunit RNA polymerases (RNAPs). Comparison of the crystal structures of a bacterial and a eukaryotic RNAP reveals a conserved core that comprises the active site and a multifunctional clamp. Together with a further structure of eukaryotic RNAP bound to DNA and RNA, these results elucidate many aspects of the transcription mechanism, including initiation, elongation, nucleotide addition, processivity and proofreading.
- Ludwig-Maximilians-Universität München Germany
- University of Göttingen Germany
Models, Molecular, Binding Sites, Transcription, Genetic, Archaeal Proteins, DNA, DNA-Directed RNA Polymerases, Protein Subunits, Structure-Activity Relationship, Eukaryotic Cells, Animals, Humans, RNA, RNA Polymerase II, Protein Structure, Quaternary
Models, Molecular, Binding Sites, Transcription, Genetic, Archaeal Proteins, DNA, DNA-Directed RNA Polymerases, Protein Subunits, Structure-Activity Relationship, Eukaryotic Cells, Animals, Humans, RNA, RNA Polymerase II, Protein Structure, Quaternary
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