Capillary electorphoresis is rapidly maturing as a major technique for the analysis of proteins, nucleic acids, and glycoconjugates. Recently, efforts have concentrated on the application of its two most powerful ancillary techniques, laser-induced fluorescence detection and mass spectrometry. In addition, affinity capillary electrophoresis is rapidly becoming popular in ligand-biomolecule binding studies. The integration of sample treatment with separation on a microchip is yet another interesting development.