Pathways to Parkinsonism
Copyright policy )Pathways to Parkinsonism
A novel gene for Parkinson's disease (PD), DJ-1, has been identified that encodes a multifunctional product with several known protein-protein interactions and effects on gene expression. Here, I outline how it is possible to construct hypotheses that place DJ-1 in different relationships to the other known PD genes, alpha-synuclein and parkin. The identification of multiple genetic causes will provide further impetus to describe the pathway leading to PD.
- National Institute on Aging United States
- National Institute of Health Pakistan
- National Institutes of Health United States
Oncogene Proteins, Protein Folding, Neuroscience(all), Protein Deglycase DJ-1, Intracellular Signaling Peptides and Proteins, Disease Models, Animal, Oxidative Stress, Parkinsonian Disorders, Mutation, Animals, Humans, Signal Transduction
Oncogene Proteins, Protein Folding, Neuroscience(all), Protein Deglycase DJ-1, Intracellular Signaling Peptides and Proteins, Disease Models, Animal, Oxidative Stress, Parkinsonian Disorders, Mutation, Animals, Humans, Signal Transduction
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