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Synaptic Plasticity and Nicotine Addiction

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2001 English Publisher:Elsevier BVJournal:Neuron, volume 31, pages 349-352 (issn: 0896-6273,

Authors: Fu-Ming Zhou; Daoyun Ji; John A. Dani;

doi: 10.1016/s0896-6273(01)00379-8

pmid: 11516393

Synaptic Plasticity and Nicotine Addiction

- Summary
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Abstract

Nicotine, the main addictive component of tobacco, activates and desensitizes nicotinic acetylcholine receptors (nAChRs). In that way, nicotine alters normal nicotinic cholinergic functions. Among the myriad of psychopharmacological effects that underlie the addiction process, nicotine influences nAChR participation in synaptic plasticity. This influence has particular importance in the mesocorticolimbic dopamine system, which serves during the reinforcement of rewarding behaviors.

Related Organizations

Baylor College of Medicine
United States

Keywords

Cerebral Cortex, Neurons, Nicotine, Neuronal Plasticity, Neuroscience(all), Dopamine, Tobacco Use Disorder, Receptors, Nicotinic, Reward, Limbic System, Animals, Humans, Nicotinic Agonists

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	238
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%