Clostridium difficile is a Gram-positive, anaerobic, spore-producing anaerobe [1] responsible for approximately 50–70% of gastrointestinal infections in hospitalized patients [2, 3]. An episode of C. difficile infection (CDI) is defined as a clinical picture compatible with CDI (i. e., diarrhea, ileus and toxic megacolon) with microbiological evidence of C. difficile (ideally free C. difficile toxins) in stool, without reasonable evidence of another cause of diarrhea, or identification of pseudomembranous colitis during endoscopy, after colectomy or on autopsy [4, 5]. Life-threatening cases are associated with severe colitis and shock, and can require intensive care unit (ICU) admission and colectomy [4, 6].