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The Clinical Significance of Platelet Membrane Glycoproteins

Name: The Clinical Significance of Platelet Membrane Glycoproteins
Creator: Rodger P. McEver
Keywords: Blood Platelets, 0301 basic medicine, 0303 health sciences, Antibodies, Monoclonal, Receptors, Cell Surface, Platelet Membrane Glycoproteins, Platelet Activation, 3. Good health, 03 medical and health sciences, 0302 clinical medicine

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1990 English Publisher:Elsevier BVJournal:Hematology/Oncology Clinics of North America, volume 4, pages 87-105 (issn: 0889-8588,

Authors: Rodger P. McEver;

doi: 10.1016/s0889-8588(18)30507-0

pmid: 2155906

The Clinical Significance of Platelet Membrane Glycoproteins

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Abstract

To mediate their hemostatic functions, platelets must adhere to exposed vascular subendothelium and then aggregate. A variety of membrane glycoprotein receptors for adhesive ligands are present on platelets that promote adhesion and aggregation. Analysis of congenital disorders of platelet glycoproteins has been instrumental in clarifying our knowledge of how these receptors function. Elucidation of the role of platelet glycoproteins in normal hemostasis has also provided insight into possible strategies for modulating receptor function in thrombotic disorders and for identifying activated platelets as markers of thrombus formation.

Related Organizations

Oklahoma Medical Research Foundation
United States
University of Oklahoma Health Sciences Center
United States

Keywords

Blood Platelets, Antibodies, Monoclonal, Receptors, Cell Surface, Platelet Membrane Glycoproteins, Platelet Activation, Fibrinolytic Agents, Humans, Blood Platelet Disorders, Platelet Aggregation Inhibitors

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	30
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%