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Hematopoietic stem cells

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2001Publisher:Elsevier BVJournal:Biomedicine & Pharmacotherapy, volume 55, pages 186-194 (issn: 0753-3322,

Authors: G. Gastl; Eberhard Gunsilius; Andreas L. Petzer;

doi: 10.1016/s0753-3322(01)00051-8

pmid: 11393804

Hematopoietic stem cells

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Abstract

The adequate production of blood cells is maintained by a set of immature hematopoietic stem cells (HSC) located in the bone marrow after birth. HSC are able to reconstitute the hematopoietic system in disease-related bone marrow failure and bone marrow aplasia. Nowadays, HSC cells can be mobilized from the bone marrow into the peripheral blood using hematopoietic cytokines, allowing a convenient harvest of these cells for clinical transplantation. This review outlines the development of the hematopoietic system in the embryo and in adults and the characterization, enumeration, purification and ex vivo expansion of HSC for clinical use. Future directions include the genetic manipulation of HSC and the identification/expansion of bone marrow-derived stem cells capable of generating non-hematopoietic tissues.

Related Organizations

University Hospital Innsbruck
Austria

Keywords

Hematopoietic Stem Cell Transplantation, Animals, Humans, Antigens, CD34, Cell Separation, Genetic Therapy, Embryo, Mammalian, Hematopoietic Stem Cells, Hematopoiesis

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	64
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%