descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2001 English Publisher:Elsevier BVJournal:Hearing Research, volume 160, pages 10-14 (issn: 0378-5955,

Authors: X Q, Jia; T, Nakashima; K, Kadomatsu; T, Muramatsu;

doi: 10.1016/s0378-5955(01)00313-6

pmid: 11591485

Expression of midkine in the cochlea

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Abstract

Midkine (MK) is one of a new family of heparin-binding growth factors involved in the regulation of growth and differentiation. We have analyzed expression of MK in the cochlea using ICR mice within 1 day from birth. The expression of MK in the cochlea was confirmed by Western blotting and immunohistochemistry. Anti-MK immunoreactivity was observed in the stria vascularis, spiral prominence, spiral ganglion, and ganglion nerve fibers. These findings suggest that MK plays a role in the development of the cochlea.

Related Organizations

Nagoya University
Japan
Tokai National Higher Education and Research System
Japan

Keywords

Mice, Inbred ICR, Blotting, Western, Midkine, Stria Vascularis, Immunohistochemistry, Cochlea, Mice, Nerve Fibers, Animals, Newborn, Animals, Cytokines, Tissue Distribution, Carrier Proteins, Spiral Ganglion, Organ of Corti

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