Quantitative structure–activity relationship (QSAR) analysis of aromatic effector specificity in NtrC-like transcriptional activators from aromatic oxidizing bacteria
Copyright policy )Quantitative structure–activity relationship (QSAR) analysis of aromatic effector specificity in NtrC-like transcriptional activators from aromatic oxidizing bacteria
A quantitative structure-activity relationship (QSAR) approach was taken to provide mechanistic insights into the interaction between the chemical structure of inducing compounds and the transcriptional activation of aromatic monooxygenase operons among the XylR/DmpR subclass of bacterial NtrC-like transcriptional regulators. Compared to XylR and DmpR, a broader spectrum of effector compounds was observed for the TbuT system from Ralstonia pickettii PKO1. The results of QSAR analysis for TbuT suggested that a steric effect, rather than hydrophobic or electronic effects, may be the predominant factor in determining aromatic effector specificity, and the active site of the regulator may positively interact not only with the methyl moiety but also with the most electron-rich aryl side of an aromatic effector.
- Michigan State University United States
- University of Michigan–Flint United States
- Rutgers, The State University of New Jersey United States
- University of Michigan–Ann Arbor United States
- University of Michigan United States
Transcriptional Activation, PII Nitrogen Regulatory Proteins, Molecular Sequence Data, Quantitative Structure-Activity Relationship, Aromatic Monooxygenase Pathway, Hydrocarbons, Aromatic, Toluene Oxidizing Bacterium, Bacterial Proteins, Bacterial NtrC-like Transcriptional Activator, Health Sciences, Operon, Promoter Regions, Genetic, Base Sequence, Gene Expression Regulation, Bacterial, Quantitative Structure–Activity Relationship, Trichloroethylene Cometabolism, Trichloroethylene, DNA-Binding Proteins, Gram-Negative Aerobic Rods and Cocci, Microbiology and Immunology, Trans-Activators, Oxidation-Reduction, Toluene, Transcription Factors
Transcriptional Activation, PII Nitrogen Regulatory Proteins, Molecular Sequence Data, Quantitative Structure-Activity Relationship, Aromatic Monooxygenase Pathway, Hydrocarbons, Aromatic, Toluene Oxidizing Bacterium, Bacterial Proteins, Bacterial NtrC-like Transcriptional Activator, Health Sciences, Operon, Promoter Regions, Genetic, Base Sequence, Gene Expression Regulation, Bacterial, Quantitative Structure–Activity Relationship, Trichloroethylene Cometabolism, Trichloroethylene, DNA-Binding Proteins, Gram-Negative Aerobic Rods and Cocci, Microbiology and Immunology, Trans-Activators, Oxidation-Reduction, Toluene, Transcription Factors
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