The detection rate of celiac disease greatly underestimates its prevalence. This is the result of lack of awareness of the many manifestations of the condition and the requirement for at least one small intestinal biopsy for diagnosis. The advent of effective serologic tests for the condition heralds a new era of non-invasive testing. The clinical utility and acceptance of these tests is limited by a lack of standardization of both the techniques used and variability of reference ranges quoted.