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Treatment of infections caused by carbapenemase-producing Enterobacteriaceae

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2014 English Publisher:Elsevier BVJournal:Enfermedades Infecciosas y Microbiología Clínica, volume 32, pages 49-55 (issn: 0213-005X,

Authors: Jesús Rodríguez-Baño; José Antonio Martínez; José Miguel Cisneros; Carlota Gudiol;

doi: 10.1016/s0213-005x(14)70174-0

pmid: 25542052

Treatment of infections caused by carbapenemase-producing Enterobacteriaceae

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Abstract

Treatment of infections caused by carbapenemase-producing Enterobacteriaceae (CPE) is currently one of the most important challenges of infectious diseases. The available information is based on in vitro studies, some animal model data and a few case studies and retrospective cohorts; appropriate data are lacking or are very scarce for some old antibiotics that are still occasionally used. Because of the heterogeneity in clinical situations, in specific carbapenemases and in the susceptibility of isolates, individualized treatment decisions must usually be made. Here we review the different antibiotics that might be useful for treating infections caused by CPE.

Related Organizations

Spanish National Research Council
Spain
Institute of Biomedicine of Seville
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Hospital Universitario Virgen Macarena
Spain
University of Barcelona
Spain
Bellvitge University Hospital
Spain

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Keywords

Enterobacteriaceae Infections, Global Health, beta-Lactam Resistance, beta-Lactamases, Anti-Bacterial Agents, Bacterial Proteins, Carbapenems, Enterobacteriaceae, Drug Resistance, Multiple, Bacterial, Models, Animal, Animals, Humans, Drug Therapy, Combination

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