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Amodiaquine-induced fulminant hepatitis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1988Publisher:Elsevier BVJournal:Journal of Hepatology, volume 6, pages 109-112 (issn: 0168-8278,

Authors: Bernard Rueff; Dominique Larrey; Claude Degott; F. Verdier; Bernard Campillo; Jacques Bernuau; Jean-Pierre Benhamou; +1 Authors

doi: 10.1016/s0168-8278(88)80469-0

pmid: 3346531

Amodiaquine-induced fulminant hepatitis

- Summary
- Subjects
- Metrics

Abstract

Three patients suffered from fulminant hepatitis within 23, 59 and 22 weeks after having ingested a total dose of 16, 26 and 15 g, respectively, of amodiaquine for the prophylaxis of malaria. Amodiaquine administration was continued for 44, 21 and 25 days after the onset of jaundice, respectively. One patient underwent emergency orthotopic liver transplantation and survived. The other two died. Fulminant hepatitis threatens patients in whom amodiaquine administration is protracted for several months and not interrupted when jaundice occurs.

Related Organizations

Beaujon Hospital
France
French Institute of Health and Medical Research
France
Assistance Publique -Hopitaux De Paris
France

Keywords

Adult, Male, Adolescent, Amodiaquine, Humans, Female, Chemical and Drug Induced Liver Injury, Middle Aged, Malaria

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	32
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average