Blockade of the nootropic action of piracetam-like nootropics by adrenalectomy: an effect of dosage?

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1989 English Publisher:Elsevier BVJournal:Behavioural Brain Research, volume 34, pages 155-158 (issn: 0166-4328,

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Authors: C, Mondadori; T, Ducret; F, Petschke;

doi: 10.1016/s0166-4328(89)80098-1

pmid: 2765169

Blockade of the nootropic action of piracetam-like nootropics by adrenalectomy: an effect of dosage?

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Abstract

The present experiments demonstrate that the absence of any memory-improving action of nootropics in adrenalectomized animals cannot be ascribed to an effect of dosage. Doses of 1, 10, 100, 1000 and 3000 mg/kg p.o. of piracetam, oxiracetam, aniracetam or pramiracetam are ineffective in adrenalectomized mice.

Related Organizations

Novartis (Switzerland)
Switzerland

Keywords

Male, Pyrrolidines, Dose-Response Relationship, Drug, Retention, Psychology, Adrenalectomy, Mice, Inbred Strains, Piracetam, Pyrrolidinones, Mice, Memory, Mental Recall, Animals, Arousal

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