descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1974 English Publisher:Elsevier BVJournal:The Lancet, volume 303, pages 705-707 (issn: 0140-6736,

Authors: J, Clemmesen; V, Fuglsang-Frederiksen; C M, Plum;

doi: 10.1016/s0140-6736(74)92906-7

pmid: 4132424

ARE ANTICONVULSANTS ONCOGENIC?

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Abstract

Abstract The duration of treatment with anti-convulsants—i.e., survival-time checked against national death files—and occurrence of neoplasms, ascertained by means of a cancer registry for 1943-67, were determined in 9136 cases of epilepsy admitted to a hospital from 1933 to 1962. Observed numbers of neoplasms were compared with expected values for study periods of less than and more than ten years. There was no evidence of an oncogenic effect.

Keywords

Male, Epilepsy, Time Factors, Denmark, Sex Factors, Neoplasms, Phenobarbital, Phenytoin, Humans, Anticonvulsants, Female, Primidone

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