CARDIOTOXICITY OF AMITRIPTYLINE
Copyright policy )CARDIOTOXICITY OF AMITRIPTYLINE
Abstract A hospital-based drug-information system has been used to extend preliminary work on the incidence of sudden unexpected death in patients with a diagnosis of cardiac disease who had been prescribed amitriptyline. The finding that there were 13 sudden unexpected deaths in a group of 119 amitriptyline patients compared with only 3 in a carefully matched control group confirms the suspicion linking unexpected death with the administration of this tricyclic antidepressant. There were 4 such deaths in a group of 87 patients receiving imipramine compared with 2 in the control group.
- University of Dundee United Kingdom
- University of Aberdeen United Kingdom
Adult, Clinical Trials as Topic, Digoxin, Imipramine, Depression, Amitriptyline, Arrhythmias, Cardiac, Heart, Middle Aged, Death, Sudden, Electrocardiography, Acute Disease, Humans
Adult, Clinical Trials as Topic, Digoxin, Imipramine, Depression, Amitriptyline, Arrhythmias, Cardiac, Heart, Middle Aged, Death, Sudden, Electrocardiography, Acute Disease, Humans
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