Publisher Summary The methods for preparing D-glucuronic acid is devised through the oxidation of derivatives of D -glucose by halogens, hydrogen peroxide, and potassium permanganate. In some of these reactions, only the aldehyde function of D-glucose is protected from oxidation, and in others the secondary hydroxyl groups also are blocked. After removal of barium with sulfuric acid, the aqueous solution of D -glucuronic acid is evaporated in vacuo to a sirup, which crystallized upon seeding with authentic D -glucuronolactone. Derivatives of D-glucose in which all the secondary hydroxyl groups are not blocked, have been used chiefly in attempts to devise an economical process for the large-scale manufacture of D -glucuronic acid. The chapter reports methods for producing D -glucuronic acid by alkaline permanganate oxidation of soluble starch, and of D -glucose derivatives in which the aldehyde function is protected.