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The biosynthesis of nicotinamide adenine dinucleotides in bacteria

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 01 Jan 2001Publisher:Elsevier BV

Authors: Andrei L. Osterman; Pieter C. Dorrestein; Cynthia Kinsland; Tadhg P. Begley; Ryan A. Mehl;

doi: 10.1016/s0083-6729(01)61003-3

pmid: 11153263

The biosynthesis of nicotinamide adenine dinucleotides in bacteria

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Abstract

The nicotinamide adenine dinucleotides (NAD, NADH, NADP, and NADPH) are essential cofactors in all living systems and function as hydride acceptors (NAD, NADP) and hydride donors (NADH, NADPH) in biochemical redox reactions. The six-step bacterial biosynthetic pathway begins with the oxidation of aspartate to iminosuccinic acid, which is then condensed with dihydroxyacetone phosphate to give quinolinic acid. Phosphoribosylation and decarboxylation of quinolinic acid gives nicotinic acid mononucleotide. Adenylation of this mononucleotide followed by amide formation completes the biosynthesis of NAD. An additional phosphorylation gives NADP. This review focuses on the mechanistic enzymology of this pathway in bacteria.

Related Organizations

Cornell University
United States

Keywords

Kinetics, Amide Synthases, Phosphotransferases, Escherichia coli, NAD, Oxidation-Reduction, NADP

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