The role of CT and MR studies in the evaluation of patients with Meniere's disease is to exclude other pathologic conditions that could masquerade as Meniere's disease clinically. This article is divided into three sections corresponding to the three major symptoms of Meniere's disease. Each section presents examples of CT and MR pathologic conditions that could mimic these clinical findings: "sensorineural hearing loss" covers acoustic neuromas and other cerebellopontine angle tumors, inner ear anomalies, otosclerosis, and more; "vertigo" includes examples of labyrinthitis, endolymphatic sac tumor, cholesteatomatous fistula, and brain metastasis; and "tinnitus" emphasizes causes of nonpulsatile tinnitus and briefly mentions pulsatile tinnitus. Each section also discusses which imaging study best addresses these specific clinical questions.