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DOPAMINE AGONISTS

Name: DOPAMINE AGONISTS
Creator: S A, Factor
Keywords: 0301 basic medicine, Indoles, Apomorphine, Parkinson Disease, Receptors, Dopamine, 3. Good health, Thiazoles, 03 medical and health sciences, Pramipexole, Treatment Outcome

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1999 English Publisher:Elsevier BVJournal:Medical Clinics of North America, volume 83, pages 415-443 (issn: 0025-7125,

Authors: S A, Factor;

doi: 10.1016/s0025-7125(05)70112-7

pmid: 10093586

DOPAMINE AGONISTS

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Abstract

Dopamine agonists have been used in the treatment of Parkinson's disease (PD) since the mid 1970s. With the approval of two new agents in 1997, the number available in the United States is up to four; bromocriptine, pergolide, pramipexole, ropinirole. These agents differ in dopamine receptor affinities and chemical structure, which, in turn, may possibly result in differences in efficacy tolerability and safety. Dopamine have historically been used in combination with levodopa in patients with advanced PD, but indicators are now expanding. With is expansion comes increasing controversy. This article reviews dopamine receptor pharmacology and the results of the clinical trials that have used for agonists available in the United States as well as a discussion of three minor agonists.

Related Organizations

Albany Medical Center Hospital
United States

Keywords

Indoles, Apomorphine, Parkinson Disease, Receptors, Dopamine, Thiazoles, Pramipexole, Treatment Outcome, Dopamine Agonists, Humans, Benzothiazoles, Bromocriptine, Pergolide, Randomized Controlled Trials as Topic

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	44
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%