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Pharmacokinetics of pentobarbital in the dog.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1983Publisher:Elsevier BVJournal:The Journal of Pharmacology and Experimental Therapeutics, volume 225, pages 355-360 (issn: 0022-3565,

Authors: M C, Frederiksen; T K, Henthorn; T I, Ruo; A J, Atkinson;

doi: 10.1016/s0022-3565(25)33596-2

pmid: 6842399

Pharmacokinetics of pentobarbital in the dog.

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Abstract

The pharmacokinetics of pentobarbital were studied after i.v. administration of a 30-mg/kg dose to five dogs. Pentobarbital plasma concentrations were measured with a new gas chromatographic method, utilizing on-column methylation of pentobarbital and as a butabarbital internal standard. The kinetics of pentobarbital distribution and elimination were analyzed with a three-compartment open mammillary model. The elimination-phase half-life of pentobarbital was 8.2 +/- 2.2 hr. The steady-state volume of pentobarbital distribution was 1.08 +/- 0.21 liters/kg and the elimination clearance was 0.0013 +/- 0.0004 liters/min X kg. Threshold pentobarbital concentrations required to suppress the corneal reflex and withdrawal response to pain were 26.4 +/- 4.6 and 23.0 +/- 2.9 micrograms/ml, respectively. These results should facilitate the design of i.v. anesthetic regimens with pentobarbital.

Keywords

Male, Blood Volume, Pain, Reflex, Pupillary, Kinetics, Dogs, Hematocrit, Anesthesia, Intravenous, Animals, Female, Pentobarbital

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