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Ochre mutants, a new class of suppressible nonsense mutants

Name: Ochre mutants, a new class of suppressible nonsense mutants
Keywords: 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article , Part of book or chapter of book , Other literature type 01 Oct 1965 English Publisher:Elsevier BVJournal:Journal of Molecular Biology, volume 13, pages 629-637 (issn: 0022-2836,

Authors: Sydney Brenner; Jon Beckwith;

doi: 10.1016/s0022-2836(65)80131-0 , 10.1016/b978-0-12-131200-8.50025-3

Ochre mutants, a new class of suppressible nonsense mutants

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Abstract

Suppressors of a strongly polar mutant of the lac gene in Escherichia coli also suppress mutants of the rII genes of bacteriophage T4. Included amongst this set are some amber mutants, but there are also many other mutants which are not suppressed by amber suppressors. These mutants are denned as ochre mutants, and the suppressors as ochre suppressors. Ochre mutants are nonsense mutants because, like the amber mutants, they abolish the B activity of the deletion r1589. This effect is not suppressed by amber suppressors, which shows that the ochre mutants are different from the amber mutants.

Related Organizations

Medical Research Council
United Kingdom
MRC Laboratory of Molecular Biology
United Kingdom

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