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Human Polynucleotide Phosphorylase, hPNPase, is Localized in Mitochondria

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2003 United Kingdom Publisher:Elsevier BVJournal:Journal of Molecular Biology, volume 329, pages 853-857 (issn: 0022-2836,

Authors: Piwowarski, Jan; Grzechnik, Pawel; Dziembowski, Andrzej; Dmochowska, Aleksandra; Minczuk, Michal; Stepien, Piotr P.;

doi: 10.1016/s0022-2836(03)00528-x

pmid: 12798676

Human Polynucleotide Phosphorylase, hPNPase, is Localized in Mitochondria

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Abstract

The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.

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United Kingdom

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Keywords

Polyribonucleotide Nucleotidyltransferase, PNPase, Cytoplasm, Polynucleotide phosphorylase, Peptide Fragments, Recombinant Proteins, Mitochondria, Protein Transport, RNA degradation, Microscopy, Fluorescence, Escherichia coli, Humans, Cloning, Molecular, HeLa Cells

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Polyribonucleotide nucleotidyltransferase 1, mitochondrial
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