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Receptor protein tyrosine kinase DDR is up‐regulated by p53 protein

descriptionPublicationkeyboard_double_arrow_right Article 02 Dec 1996Publisher:WileyJournal:FEBS Letters, volume 398, pages 165-169 (issn: 0014-5793, eissn: 1873-3468,

Authors: Shirou Sakuma; Hiroshi Abe; Mitsuyoshi Nakao; Yumiko Shinohe; Hideyuki Saya; Toshiyoshi Fujiwara; Yutaka Sawamura; +2 Authors

doi: 10.1016/s0014-5793(96)01234-3

pmid: 8977099

Receptor protein tyrosine kinase DDR is up‐regulated by p53 protein

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Abstract

We have previously reported on radiation‐induction of ptk‐3 in rat astrocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1–7]. Ptk‐3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirusmediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up‐regulated by the p53 protein.

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Keywords

Genomic DNA structure, Molecular Sequence Data, Chromosome Mapping, Receptor Protein-Tyrosine Kinases, Human DDR gene, Blotting, Northern, Genes, p53, Transfection, Up-Regulation, Receptors, Mitogen, Tumor Cells, Cultured, Humans, Cloning, Molecular, Tumor Suppressor Protein p53, p53 regulatory element, Promoter Regions, Genetic, Discoidin Domain Receptors

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6 Research products, page 1 of 1

Radiation Induction of the Receptor Tyrosine Kinase Gene Ptk-3 in Normal Rat Astrocytes
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