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Brain Research
Article . 1997 . Peer-reviewed
License: Elsevier TDM
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Brain Research
Article . 1997
Data sources: Europe PubMed Central
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Postsynaptic blockade of inhibitory postsynaptic currents by plasmin in CA1 pyramidal cells of rat hippocampus

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1997Publisher:Elsevier BVJournal:Brain Research, volume 761, pages 93-96 (issn: 0006-8993, Copyright policy )
Authors: Norio Matsuki; Tatsuro Tanaka; Akio Mizutani; Hiroshi Saito;

doi: 10.1016/s0006-8993(97)00338-7

pmid: 9247070

Postsynaptic blockade of inhibitory postsynaptic currents by plasmin in CA1 pyramidal cells of rat hippocampus

Abstract

We have shown previously that plasmin facilitated the generation of long-term potentiation (LTP) in CA1 and dentate region of rat hippocampus. In the present study, we investigated the effects of plasmin on postsynaptic currents in CA1 pyramidal neurons of rat hippocampal slices. Plasmin (100 nM) had no effect on NMDA nor on non-NMDA receptor-mediated excitatory postsynaptic currents. However, plasmin significantly decreased GABA(A) receptor-mediated inhibitory postsynaptic currents. This effect of plasmin disappeared when intracellular Ca2+ was strongly chelated with BAPTA. Furthermore, plasmin attenuated the GABA-induced currents in CA1 pyramidal cells. These results suggest that the STP-enhancing effect of plasmin is due to a blockade of postsynaptic GABA(A) responses and that an increase in intracellular Ca2+ by plasmin may be involved in its mechanism.

Related Organizations
Keywords

Patch-Clamp Techniques, Pyramidal Cells, Neural Inhibition, Synaptic Transmission, Electric Stimulation, Rats, Fibrinolytic Agents, Dentate Gyrus, Animals, Fibrinolysin, Rats, Wistar, gamma-Aminobutyric Acid

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    		 13
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    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
13
Average
Average
Average
Related to Research communities
Neuroscience
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