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Experimental production of anemia in fetal lambs

Name: Experimental production of anemia in fetal lambs
Keywords: Erythroblastosis, Fetal, Anemia, Hemolytic, Sheep, Pregnancy, Exchange Transfusion, Whole Blood, Animals, Edema, Female, Hemorrhage, Fetal Death

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1968Publisher:Elsevier BVJournal:American Journal of Obstetrics and Gynecology, volume 100, pages 686-695 (issn: 0002-9378,

Authors: Donald L. Hutchinson; Urabala Boonyaprakob; Iain R. McFadyen;

doi: 10.1016/s0002-9378(15)33393-7

pmid: 5638488

Experimental production of anemia in fetal lambs

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Abstract

An attempt has been made to produce an experimental model in the fetal lamb which would simulate the physicochemical and pathologic phenomena associated with the severe anemia and hydrops seen in severe human erythroblastosis. Profound anemia was obtained by repeated fetal phlebotomy. Hemolytic anemia was induced in the fetal lamb by direct administration of phenylhydrazine, without discernible effect on the health of the maternal ewe. Hydrops fetalis has not been observed after either chronic fetal bleeding or with phenylhydrazine-induced anemia.

Related Organizations

University of Pittsburgh
United States
Woman's Hospital
United States

Keywords

Erythroblastosis, Fetal, Anemia, Hemolytic, Sheep, Pregnancy, Exchange Transfusion, Whole Blood, Animals, Edema, Female, Hemorrhage, Fetal Death, Phenylhydrazines

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