Identifying and characterizing Hfq–RNA interactions
Copyright policy )Identifying and characterizing Hfq–RNA interactions
To regulate stress responses and virulence, bacteria use small regulatory RNAs (sRNAs). These RNAs can up or down regulate target mRNAs through base pairing by influencing ribosomal access and RNA decay. A large class of these sRNAs, called trans-encoded sRNAs, requires the RNA binding protein Hfq to facilitate base pairing between the regulatory RNA and its target mRNA. The resulting network of regulation is best characterized in Escherichia coli and Salmonella typhimurium, but the importance of Hfq dependent sRNA regulation is recognized in a diverse population of bacteria. In this review we present the approaches and methods used to discover Hfq binding RNAs, characterize their interactions and elucidate their functions.
- Wayne State University United States
- Wayne State College United States
Models, Molecular, Proteomics, Bacteria, Gene Expression Profiling, SELEX Aptamer Technique, Electrophoretic Mobility Shift Assay, Gene Expression Regulation, Bacterial, Host Factor 1 Protein, RNA, Bacterial, Immunoprecipitation, RNA, Small Untranslated, Protein Binding
Models, Molecular, Proteomics, Bacteria, Gene Expression Profiling, SELEX Aptamer Technique, Electrophoretic Mobility Shift Assay, Gene Expression Regulation, Bacterial, Host Factor 1 Protein, RNA, Bacterial, Immunoprecipitation, RNA, Small Untranslated, Protein Binding
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