Molecular imaging targeting peptide receptors

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2009 English Publisher:Elsevier BVJournal:Methods, volume 48, pages 161-177 (issn: 1046-2023,

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Authors: Margret, Schottelius; Hans-Jürgen, Wester;

doi: 10.1016/j.ymeth.2009.03.012

pmid: 19324088

Molecular imaging targeting peptide receptors

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Abstract

Overexpressed neuropeptide receptors allow tumor visualization using e.g. radiolabeled peptidic receptor ligands and positron emission tomography (PET) or single photon emission computed tomography (SPECT). This review summarizes the development of radiolabeled probes for peptide receptor imaging since the emergence of the technology with a particular focus on peptide radiopharmaceuticals developed during the last 5 years, and highlights the different factors which are decisive during the process of tracer development and evaluation.

Related Organizations

Technical University of Munich
Germany
Rechts der Isar Hospital
Germany
TECHNISCHE UNIVERSITAET MUENCHEN
Germany

Keywords

Tomography, Emission-Computed, Single-Photon, Molecular Diagnostic Techniques, Receptors, Peptide, Neoplasms, Positron-Emission Tomography, Models, Animal, Molecular Sequence Data, Animals, Humans, Amino Acid Sequence, Radiopharmaceuticals

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