Cause of death: suicide

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2006 English Publisher:Elsevier BVJournal:Journal of Molecular and Cellular Cardiology, volume 40, pages 425-437 (issn: 0022-2828,

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Authors: Jan, Kajstura; Roberto, Bolli; Edmund H, Sonnenblick; Piero, Anversa; Annarosa, Leri;

doi: 10.1016/j.yjmcc.2005.12.013

pmid: 16513132

Cause of death: suicide

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Abstract

In the last decade, apoptosis has gained recognition as an important event determining the structure and function of the myocardium. The purpose of this review is to provide insights into the mechanisms controlling programmed cell death of myocytes. In this regard, the role of the local renin-angiotensin system and oxidative stress is emphasized. Moreover, the effect of cell death on ventricular remodeling and performance is analyzed. The impact of the identification of apoptosis in the heart on the current view of myocardium as a dynamic organ is discussed.

Related Organizations

New York Medical College
United States

Keywords

Renin-Angiotensin System, Oxidative Stress, Ventricular Remodeling, Myocardium, Animals, Humans, Apoptosis, Myocytes, Cardiac

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