The first evidence of an association between a polymorphism in the endocannabinoid-degrading enzyme FAAH (FAAH rs2295633) with attention deficit hyperactivity disorder
Copyright policy )The first evidence of an association between a polymorphism in the endocannabinoid-degrading enzyme FAAH (FAAH rs2295633) with attention deficit hyperactivity disorder
Several single nucleotide polymorphisms (SNPs) of the fatty acid amide hydrolase (FAAH), the degrading enzyme of the endocannabinoids, have been shown to be associated with many neuropsychiatric disorders. Here, FAAH rs2295633 was studied in ADHD and case-control healthy children. There was a significant difference in the allele frequency (P = .04) and genotype distribution (P = .04) of the FAAH rs2295633 between ADHD cases and controls. The ADHD children appeared to have less of TT genotype (OR 0.396, 95% CI 0.178-0.884, p = .024) and T allele (OR 0.658, 95% CI 0.440-0.982, p = .04). To our best knowledge, this is the first statistical significant association between FAAH rs2295633 genotype and ADHD disorder. Larger sample sizes and functional studies are warranted to explore the clinical utility of FAAH genotyping as a possible marker for increased ADHD risk in children.
- University of Maragheh Iran (Islamic Republic of)
- Tabriz University of Medical Sciences Iran (Islamic Republic of)
- University of Tabriz Iran (Islamic Republic of)
- Maragheh University of Medical Sciences Iran (Islamic Republic of)
Male, Attention Deficit Disorder with Hyperactivity, Humans, Female, Child, Polymorphism, Single Nucleotide, Fatty Acid Amide Hydrolases, Amidohydrolases
Male, Attention Deficit Disorder with Hyperactivity, Humans, Female, Child, Polymorphism, Single Nucleotide, Fatty Acid Amide Hydrolases, Amidohydrolases
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