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Genomics
Article . 2007 . Peer-reviewed
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Genomics
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Genomics
Article . 2007
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Genomics
Article . 2007
License: Elsevier Non-Commercial
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Genomics
Article . 2007
Data sources: Pure Amsterdam UMC
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Resolving the resolution of array CGH

Authors: Coe, Bradley P.; Ylstra, Bauke; Carvalho, Beatriz; Meijer, Gerrit A.; MacAulay, Calum; Lam, Wan L.;

Resolving the resolution of array CGH

Abstract

Many recent technologies have been designed to supplant conventional metaphase CGH technology with the goal of refining the description of segmental copy number status throughout the genome. However, the emergence of new technologies has led to confusion as to how to describe adequately the capabilities of each array platform. The design of a CGH array can incorporate a uniform or a highly variable element distribution. This can lead to bias in the reporting of average or median resolutions, making it difficult to provide a fair comparison of platforms. In this report, we propose a new definition of resolution for array CGH technology, termed "functional resolution," that incorporates the uniformity of element spacing on the array, as well as the sensitivity of each platform to single-copy alterations. Calculation of these metrics is automated through the development of a Java-based application, "ResCalc," which is applicable to any array CGH platform.

Country
Netherlands
Keywords

Gene dosage, DNA arrays, Technology Assessment, Biomedical, Genome, Human, Loss of heterozygosity, Gene Dosage, Loss of Heterozygosity, Nucleic Acid Hybridization, Technology assessment, Nucleic acid hybridization, Sensitivity and Specificity, Genomic hybridizations, Genetics, Humans, Genetic techniques, Oligonucleotide Array Sequence Analysis

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    155
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
155
Top 10%
Top 1%
Top 1%
Green
gold