MicroRNAs in chronic lymphocytic leukemia

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2011 English Publisher:Elsevier BVJournal:Experimental and Molecular Pathology, volume 90, pages 173-178 (issn: 0014-4800,

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Authors: Brian P, Ward; Gregory J, Tsongalis; Prabhjot, Kaur;

doi: 10.1016/j.yexmp.2010.12.002

pmid: 21168405

MicroRNAs in chronic lymphocytic leukemia

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Abstract

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world. Recent research, conducted primarily in basic science laboratories, has indicated a role for microRNAs (miRNAs) in the pathogenesis and prognosis of this disease. MiRNAs are small, non-coding, functional RNAs, that mediate post-transcriptional inhibition of messenger RNAs. Because miRNA expression levels in CLL patients differ from that of normal patients, there may be a role for these novel small molecules as biomarkers in this disease.

Related Organizations

Dartmouth–Hitchcock Medical Center
United States
Dartmouth College
United States

Keywords

MicroRNAs, Drug Resistance, Neoplasm, Humans, Tumor Suppressor Protein p53, Prognosis, Leukemia, Lymphocytic, Chronic, B-Cell

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