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The status and role of ErbB receptors in human cancer

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2008Publisher:Elsevier BVJournal:Experimental and Molecular Pathology, volume 84, pages 79-89 (issn: 0014-4800,

Authors: Marian Hajduch; Jitka Berkovcová; Radek Trojanec; Ivo Uberall; Zdenek Kolar;

doi: 10.1016/j.yexmp.2007.12.002

pmid: 18279851

The status and role of ErbB receptors in human cancer

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Abstract

Changes in the expression of cellular receptors contribute to the progression of many types of solid tumors. In this review, we focus on the normal role of ErbB receptors as signal transducers and their contribution to carcinogenesis when there are abnormalities in ErbB signaling due to the overactivity of the receptors or the overexpression of ligands, which can lead to developmental defects and have been associated with many types of cancers.

Related Organizations

University Hospital Olomouc
Czech Republic
Molecular Pathology Laboratory Network (United States)
United States
Palacký University, Olomouc
Czech Republic

Keywords

ErbB Receptors, Male, Mice, Neoplasms, Biomarkers, Tumor, Animals, Humans, Female, Signal Transduction

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	79
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%