descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2014 English Publisher:Elsevier BVJournal:Experimental Cell Research, volume 329, pages 234-238 (issn: 0014-4827,

Authors: Seka S, Lazare; Edyta E, Wojtowicz; Leonid V, Bystrykh; Gerald, de Haan;

doi: 10.1016/j.yexcr.2014.08.033

pmid: 25192911

microRNAs in hematopoiesis

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Abstract

miRNAs have been implicated in all stages of hematopoiesis including maintenance of self-renewal of hematopoietic stem cells (HSCs) and differentiation into mature blood cells. Regulation by miRNAs is markedly intertwined with transcription factors. In this review, we highlight miRNAs shown to be important for HSC maintenance and lineage differentiation with focus on their interaction with transcription factors. We also pay attention to the diverse modes of miRNA regulation.

Related Organizations

University Medical Center Groningen
Netherlands
University of Groningen
Netherlands

Keywords

MicroRNAs, Animals, Humans, Cell Differentiation, Cell Lineage, Hematopoietic Stem Cells, Hematopoiesis

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