P ediatric chronic pain has been an increasingly significant problem over the last 5 years. It is estimated to occur in 15% to 30% of school-age children [1]. Pain is not only a significant emotional stressor for the family unit but also an expensive one. Lost work from parental absences to care for the child as well as increasing costs of health care use are significant. There is increasing evidence that the development of chronic pain in childhood may lead to chronic pain as an adult. The behavioral consequences of school absences, changed peer relationships, effects on social activities, and effects on family interactions affect the child, his siblings, and his future. It is important to recognize that in the pediatric population, nonorganic factors may be as important as organic factors in maintaining pain and that both need to be addressed. Because all pain involves neurosensory changes and may involve altered pain processing, the use of ‘‘organic’’ or ‘‘medical’’ versus ‘‘nonorganic’’ is probably artificial. While most parents prefer a biologic explanation for pain, a multifactorial approach to pain management usually leads to the best results. Each pediatric age seems to have a significant area of pain during specific ages. Infants frequently have colic. Stomach ache and headache are frequent chronic complaints in young childrenwhodo notwish to leave the home and go to school, and can usually be handled by the pediatrician. Headaches and musculoskeletal pains are commonly seen in adolescents [2]. The authors discuss problems that frequently occur in preteens and adolescents. Frequent presenting chronic complaints include headache, abdominal pain, musculoskeletal pain (including back pain), and limb pain thought to be complex regional pain syndrome. Cancer survivors with ongoing neuropathic pain are an increasingly large group, a result of the improved cancer cure rates. A few patients have genetic illnesses