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Immunogenicity of Protein Pharmaceuticals

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2019 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 108, pages 1,637-1,654 (issn: 0022-3549,

Authors: Robert K. Dingman; Sathy V. Balu-Iyer;

doi: 10.1016/j.xphs.2018.12.014

pmid: 30599169

pmc: PMC6720129

Immunogenicity of Protein Pharmaceuticals

- Summary
- Subjects
- Metrics

Abstract

Protein therapeutics have drastically changed the landscape of treatment for many diseases by providing a regimen that is highly specific and lacks many off-target toxicities. The clinical utility of many therapeutic proteins has been undermined by the potential development of unwanted immune responses against the protein, limiting their efficacy and negatively impacting its safety profile. This review attempts to provide an overview of immunogenicity of therapeutic proteins, including immune mechanisms and factors influencing immunogenicity, impact of immunogenicity, preclinical screening methods, and strategies to mitigate immunogenicity.

Related Organizations

State University of New York at Potsdam
United States
University of Chicago
United States

Keywords

Antibody Formation, Animals, Humans, Proteins, Antibodies

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	114
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%