To present the authors' experience in surgical treatment of patients with trigeminal neuralgia (TN) with intraneural vessels.The study included three patients with TN and an intraneural artery (superior cerebellar artery) and eight patients with TN and an intraneural vein. The patients underwent microvascular decompression (MVD) procedures. The intraneural arteries were wrapped by a thin piece of Teflon sponge. The intraneural veins all were coagulated and divided. Clinical outcomes and postoperative complications were analyzed.Eight patients were free of facial pain soon after surgery, achieving excellent outcomes; two patients had good outcomes; and one patient had a failed first operation but experienced pain relief after reoperation, achieving an excellent outcome. Three patients had postoperative facial numbness because the trigeminal nerves were impaired owing to coagulation or mechanical injury. However, no dense corneal numbness or loss of corneal reflex occurred.If the intraneural vessel is an artery, it can be decompressed by wrapping techniques. Otherwise, intraneural veins should be coagulated and divided. Most patients can achieve excellent or good pain relief with this approach; facial numbness is uncommon.