Abstract Objective To observe the clinical efficacy of knee joint pain treated with scraping combined with collateral bloodletting therapy in comparison with the routine acupuncture techniques. Methods From March 2017 through to September 2017, 60 outpatients of knee joint pain were collected from the Acupuncture-Moxibustion Department. They were randomly divided into the group A (treated with scraping combined with collateral bloodletting therapy) and the group B (treated with the simple needling therapy of acupuncture), 30 cases in each one. Once treatment was given every day and 10 times consist of one course, two courses of treatment were required. At the end of treatment, the visual analogue scale (VAS) was adopted to evaluate the pain index, tenderness index and the overall effect of the patients in the two groups. Based on the Lysholm knee scale, the scores were compared in the patients of the two groups before and after treatment. Results The total effective rate was 96.7% in the group A and was 86.7% in the group B, indicating the significant difference (P Conclusion The scraping combined with collateral bloodletting therapy is significant in the efficacy on knee joint pain and feasible in the clinical guidance.