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Ovis aries Papillomavirus 3: A prototype of a novel genus in the family Papillomaviridae associated with ovine squamous cell carcinoma

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2010 Italy English Publisher:Elsevier BVJournal:Virology, volume 407, pages 352-359 (issn: 0042-6822,

Authors: Alberti A.; Pirino S.; Pintore F.; Addis M. F.; Chessa B.; Cacciotto C.; Cubeddu T.; +7 Authors

doi: 10.1016/j.virol.2010.08.034

pmid: 20863546

handle: 2434/492873 , 11388/47296 , 11585/883318

Ovis aries Papillomavirus 3: A prototype of a novel genus in the family Papillomaviridae associated with ovine squamous cell carcinoma

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Abstract

Papillomaviruses play an important role in human cancer development, and have been isolated from a number of animal malignancies. However, the association of papillomaviruses with tumors has been poorly investigated in sheep. In this study, a novel ovine Papillomavirus, OaPV3, was cloned from sheep squamous cell carcinoma. Unlike the already known ovine papillomaviruses, belonging to the Delta genus, OaPV3 lacks the E5 open reading frame and maintains the conserved retinoblastoma motif in the E7 gene. OaPV3 infects exclusively epithelial cells, and was found in skin of healthy sheep of geographically separated flocks located in Sardinia (Italy). This new virus is transcriptionally active in tumors and shares low homology with all the other papillomaviruses, establishing a new genus. Taken together, the co-occurrence of OaPV3 and tumors, its cell and tissue tropism, and its gene repertoire, suggests a role for this virus in development of sheep squamous cell carcinoma.

Country

Italy

Related Organizations

Università degli studi di Salerno
Italy
PORTO CONTE RICERCHE SRL
Italy
University of Sassari
Italy
Alma Mater Studiorum University of Bologna
Italy
University of Milan
Italy

Keywords

Skin Neoplasms, Molecular Sequence Data, Sheep Diseases, In-situ Hybridization, Artiodactyl papillomavirus; Biodiversity; In-situ Hybridization; Phylogeny; Rolling circle amplification; Sheep; Skin cancer, Species Specificity, Virology, Skin cancer, Animals, Artiodactyl papillomavirus; Biodiversity; In-situ Hybridization; Phylogeny; Rolling circle amplification; Sheep; Skin cancer; Animals; Carcinoma, Squamous Cell; Cloning, Molecular; DNA, Viral; Epithelial Cells; Molecular Sequence Data; Papillomaviridae; Papillomavirus Infections; Phylogeny; Sequence Analysis, DNA; Sheep; Sheep Diseases; Sheep, Domestic; Skin Neoplasms; Species Specificity; Virology; Medicine (all), Cloning, Molecular, Papillomaviridae, Phylogeny, Sheep, Domestic, Sheep, Papillomavirus Infections, Epithelial Cells, Biodiversity, Sequence Analysis, DNA, DNA, Viral, Carcinoma, Squamous Cell, Artiodactyl papillomavirus, Rolling circle amplification

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