descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2010 English Publisher:Elsevier BVJournal:Veterinary Microbiology, volume 141, pages 115-119 (issn: 0378-1135,

Authors: Johnson, Amber M.; Kaushik, Radhey S.; Hardwidge, Phillip R.;

doi: 10.1016/j.vetmic.2009.08.020

pmid: 19733985

Disruption of transepithelial resistance by enterotoxigenic Escherichia coli

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Abstract

Transepithelial resistance and tight junction protein localization in porcine intestinal epithelial cells were evaluated as a function of infection with porcine enterotoxigenic Escherichia coli isolates differing in adhesin and enterotoxin profiles. Robust heat-labile enterotoxin-independent reduction of host transepithelial resistance was observed in the absence of tight junction protein mislocalization.

Related Organizations

University of Kansas
United States
University of Kansas Medical Center
United States
South Dakota State University
United States

Keywords

enterotoxigenic Escherichia coli, Veterinary Medicine, 570, bacterial pathogenesis, Swine, tight junction, Blotting, Western, transepithelial resistance, Epithelial Cells, 630, Cell Line, Tight Junctions, Intestines, Microscopy, Fluorescence, Animals, Enterotoxigenic Escherichia coli

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