Canine IgE discovery and characterization historically closely paralleled that of human IgE. The reason for this would seem to be the early recognition of the spontaneous manifestation of allergic diseases in dogs that are nearly identical to human allergic diseases. The discovery and characterization of human IgE being dependent upon its biological activity in sensitizing mast cells and basophils was matched early on by analogous approaches readily applied to dogs. Following the early work on IgE, cloning and sequencing of the IgE heavy chain, epsilon, lagged well behind the human and rodent for want of IgE producing canine myelomas. As with human allergic diseases, measurement of allergen-specific and total IgE in canine tissues and body fluids revealed the same associations with various disease manifestations that some times defied discovery of straight-forward cause and effect relationships because of the complexity of pathogenesis in spontaneous allergic disease. However it is clear that research on IgE in spontaneously allergic dogs offers many opportunities to explore novel immunotherapeutic approaches to the control of allergic disease that will benefit both dogs and humans.