Diethylhexyl phthalate impairs insulin binding and glucose oxidation in Chang liver cells

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2007 English Publisher:Elsevier BVJournal:Toxicology in Vitro, volume 21, pages 99-102 (issn: 0887-2333,

Copyright policy )

Authors: Srinivasan, Rengarajan; Chandrakesan, Parthasarathy; Malat, Anitha; Karundevi, Balasubramanian;

doi: 10.1016/j.tiv.2006.07.005

pmid: 16956746

Diethylhexyl phthalate impairs insulin binding and glucose oxidation in Chang liver cells

- Summary
- Subjects
- Metrics

Abstract

The present study examined the dose-dependent effects of diethylhexyl phthalate (DEHP) on insulin receptor concentration and glucose oxidation in Chang liver cells. Chang liver cells (5 x 10(5) cells) were exposed to different concentrations (0, 50, 100, 200 and 400 microM) of DEHP for 24h. At the end of exposure, cells were utilized for assessing insulin receptor concentration and glucose oxidation. Both insulin receptor concentration and glucose oxidation in Chang liver cells were significantly reduced by high doses (200 and 400 microM) of phthalate exposure. The present study is first of its kind to report the direct adverse effects of DEHP on insulin receptor and glucose oxidation in Chang liver cells and suggests that DEHP exposure may have a negative influence on glucose homeostasis.

Related Organizations

University of Madras
India

Keywords

Dose-Response Relationship, Drug, Cell Survival, Receptor, Insulin, Cell Line, Rats, Glucose, Liver, Diethylhexyl Phthalate, Hepatocytes, Animals, Insulin, Oxidation-Reduction

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	43
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average