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Trends in Pharmacological Sciences
Article . 2024 . Peer-reviewed
License: CC BY
Data sources: Crossref
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ZENODO
Other literature type . 2024
License: CC BY
Data sources: ZENODO
ZENODO
Other literature type . 2024
License: CC BY
Data sources: Datacite
ZENODO
Other literature type . 2024
License: CC BY
Data sources: Datacite
https://pubmed.ncbi.nlm.nih.go...
Article . 2024
Data sources: Europe PubMed Central
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Claim

Novel antagonists reveal the mechanism of PXR inhibition

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Nov 2024 English Publisher:Elsevier BVJournal:Trends in Pharmacological Sciences, volume 45, pages 961-963 (issn: 0165-6147, Copyright policy )
Authors: Pavek, Petr; Kamaraj, Rajamanikkam;

doi: 10.1016/j.tips.2024.10.002 , 10.5281/zenodo.14056166 , 10.5281/zenodo.14056165

pmid: 39419741

Novel antagonists reveal the mechanism of PXR inhibition

Abstract

The pregnane X receptor (PXR) is a key regulator of metabolism, but the mechanisms underlying its antagonism remain unclear. Garcia-Maldonado et al. reported potentnew antagonists and their cocrystal structures, revealing molecular determinants of PXR antagonism and paving the way for developing antagonists as therapeutics and preventing undesirable PXR activation.

Related Organizations
Keywords

Pregnane X Receptor, Humans, Animals

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 4
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Top 10%
Average
Average
hybrid